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Centrin 2 Polyclonal Antibody from Invitrogen for Immunohistochemistry applications. This antibody reacts with Human samples. Supplied as 100 µl purified antibody ( mg/mL) in PBS with 40% glycerol and % sodium azide; pH
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Centrin is a key regulator of centriole duplication. This protein is localized to the centrosome of interphase cells. During mitosis, centrin redistributes to the spindle poles, consistent with dynamic changes of the centrosome during the cell cycle.
title = "Control of centrin stability by Aurora A", abstract = "Aurora A is an oncogenic serine/threonine kinase which can cause cell transformation and centrosome amplification when overexpressed. Human breast tumors show excess Aurora A and phosphocentrin in amplified centrosomes.
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Plasmid pLVXFLAGmCherryC1centrin1 from Dr. Manuel Thery's lab contains the insert centrin1 and is published in Unpublished This plasmid is available through Addgene.
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Plasmid pEGFPcentrin1 from Dr. Michel Bornens's lab contains the insert centrin1 and is published in Unpublished This plasmid is available through Addgene.
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Caltractin belongs to a family of calciumbinding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubuleorganizing center, possibly required for the proper duplication and segregation of the centrosome.
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